Compound name
BAY-403
Protein family
GPCR
Target name
PTGFR
Affinity biochemical (nM)
10000
Affinity on-target cellular (nM)
1200
CG-Set
GPCR set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001131a
SMILES
Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl
InChIKey
ZZSNHHKTFMLWFY-KRWDZBQOSA-N
NCBI gene ID
5737
UniProt ID
P43088
Synonyms
FP
Mode of action
Negative control for BAY-6672
Affinity biochemical definition
IC50
Affinity biochemical assay type
Panlabs hFP-R binding assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-6672
Affinity biochemical relation
>
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Human FP-R assay (Chem-1 cells expressing human FP receptor, Eurofins)
Affinity on-target cellular source knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00834
Affinity on-target cellular relation
0
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(HTR3A) = 584.83 nM, Ki(TMEM97) = 1099.22 nM, Ki(ADRA2A) = 8468.01 nM
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00834
Selectivity Number of Off-targets
0