Compound name
BAY-9897
Protein family
Ion Channel
Target name
TRPA1
Affinity biochemical (nM)
25000
CG-Set
Ion Channel
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001132a
SMILES
COc1cc(N[C@@H]2CCCC[C@]2(O)C(F)(F)F)ccc1F
InChIKey
CWRARANSONEPBZ-CHWSQXEVSA-N
NCBI gene ID
8989
UniProt ID
O75762
Synonyms
TRPA1, ANKTM1
Mode of action
Negative control for BAY-390
Affinity biochemical definition
IC50
Affinity biochemical assay type
FLIPR Ca2+ assay (human TRPA1 overexpressing cell line CHO hTRPA1 GCaMP6)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-390
Affinity biochemical relation
>
Selectivity platform
GPCR panel (PDSD screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potency of closest target: Ki(HRH2) = 9781.38 nM; Selectivity against family members in biochemical assays, all >30 fold: IC50(hTRPV1) >25 µM, IC50(hTRPV4) >25 µM, IC50(hTRPC3) n.d., IC50(hTRPC5) = 10.0 µM, IC50(hTRPC6) >30 µM, IC50(hKCNK9 (TASK-3)) n.d., IC50(hCACNA1H (Cav3.2)) n.d.
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-390
Selectivity Number of Off-targets
0