Compound name
GSK791
Protein family
Bromodomain
Target name
BRD2@BD1
Affinity biochemical (nM)
2512
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001133a
SMILES
Cc1cc2c(-c3ccco3)cnc(N[C@H]3CCN(C)C[C@@H]3C(=O)NC3CCCCC3)c2[nH]c1=O
InChIKey
NDEORODKVUYMFQ-SFTDATJTSA-N
NCBI gene ID
6046
UniProt ID
P25440
Synonyms
KIAA9001, RING3, D6S113E, NAT, FSRG1
Mode of action
Negative control for GSK789
Affinity biochemical definition
IC50
Affinity biochemical assay type
BET mutant TR-FRET assay (BD1)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/GSK789
Affinity biochemical relation
0
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potency of closest target: KI(GABA/BZP) = 2539.22 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/GSK789
Selectivity Number of Off-targets
0