Compound name
GSK791
Protein family
Bromodomain
Target name
BRD4@BD1
Affinity biochemical (nM)
1585
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001133a
SMILES
Cc1cc2c(-c3ccco3)cnc(N[C@H]3CCN(C)C[C@@H]3C(=O)NC3CCCCC3)c2[nH]c1=O
InChIKey
NDEORODKVUYMFQ-SFTDATJTSA-N
NCBI gene ID
23476
UniProt ID
O60885
Synonyms
HUNKI, MCAP, CAP, HUNK1
Mode of action
Negative control for GSK789
Affinity biochemical definition
IC50
Affinity biochemical assay type
BET mutant TR-FRET assay (BD1)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/GSK789
Affinity biochemical relation
0
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potency of closest target: KI(GABA/BZP) = 2539.22 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/GSK789
Selectivity Number of Off-targets
0