Compound name
GSK943
Protein family
Bromodomain
Target name
BRD2@BD2
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001134a
SMILES
CNC(=O)c1cc(C(=O)N[C@@H]2[C@H]3COC[C@H]32)cc2c1O[C@@H](CF)[C@@H]2c1ccccc1
InChIKey
WZQLVEPIBAOOGF-PXTPFGJHSA-N
NCBI gene ID
6046
UniProt ID
P25440
Synonyms
KIAA9001, RING3, D6S113E, NAT, FSRG1
Mode of action
Negative control for GSK973
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potency of closest target: Ki(GABA/BZP) = 473.91 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/GSK973
Selectivity Number of Off-targets
0