Compound name
Retinoic acid
Protein family
NR
Target name
RARB
Affinity on-target cellular (nM)
360
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001136a
SMILES
CC1(C(=C(CCC1)C)C=CC(=CC=CC(=CC(O)=O)C)C)C
InChIKey
SHGAZHPCJJPHSC-UHFFFAOYSA-N
NCBI gene ID
5915
UniProt ID
P10826
Synonyms
HAP, NR1B2, RRB2
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1074/jbc.M205016200
https://doi.org/10.1016/j.bmcl.2014.09.053
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
rem. activity(RORA) = 0.56, rem. activity(RORB) = 0.53, rem. activity(RORC) = 0.46, rel. activity(RXRA)=30.83% to bexarotene 1 µM, rem. activity(NR2E1) = 0.42, rem. activity(NR5A1) = 0.42, inactive at 1 µM for UL48, HNF4A, NR2C1, NR4A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
6