Compound name
Tiratricol
Protein family
NR
Target name
THRA
Affinity on-target cellular (nM)
2
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001139a
SMILES
OC(CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)=O
InChIKey
UOWZUVNAGUAEQC-UHFFFAOYSA-N
NCBI gene ID
7067
UniProt ID
P10827
Synonyms
EAR-7.1/EAR-7.2, THRA3, AR7, ERBA, NR1A1
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1002/jat.2825
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR5A1)=2.0, inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1