Compound name
GW 590735
Protein family
NR
Target name
PPARA
Affinity on-target cellular (nM)
4
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001141a
SMILES
O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F
InChIKey
ILUPZUOBHCUBKB-UHFFFAOYSA-N
NCBI gene ID
5465
UniProt ID
Q07869
Synonyms
hPPAR, NR1C1
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm058056x
https://doi.org/10.1016/j.bmc.2011.03.053
https://doi.org/10.1016/j.bmcl.2010.11.030
https://doi.org/10.1016/j.bmcl.2008.09.094
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(PPARG) = 2.82, inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1