Compound name
Bavachinin
Protein family
Nuclear Receptors
Target name
NR1C3
Affinity on-target cellular (nM)
738
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001143a
SMILES
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C1C=C(C/C=C(C)/C)C(OC)=C3
InChIKey
VOCGSQHKPZSIKB-FQEVSTJZSA-N
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Reporter gene assay (HEK293T cells were cotransfected with pREP7 reporter plasmid and hPPAR? expression plasmid)
Affinity on-target cellular source knowledge
https://doi.org/10.1007/s00125-016-3912-9
Affinity on-target cellular relation
0
Selectivity platform
Nuclear receptor panel, bromodomain and kinase panel
Selectivity platform number of targets
20
Selectivity remarks
Screened at 1 µM against NR1C1, NR1C2, NR2A1, NR2B1, NR2C1, NR2E1, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV containing the Gal4-DBD fused with human NR-LBD of interest or pECE-SV40-Gal4-VP16): clean selectivty profile with no significant agonism/antagonism detected; Screened at 20 µM in a bromodomain and kinase panel against ABL1, AURKA, BRD4, BRPF1, CDK2, CSNK1D, FGFR3, GSK3B, MAPK1, TRIM24 in DSF assays: ?Tm(FGFR3) = 2.85; all other bromodomains or kinases ?Tm < 2 K
Selectivity Number of Off-targets
1