Compound name
Elafibranor
Protein family
NR
Target name
PPARD
Affinity on-target cellular (nM)
210
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001147a
SMILES
CSC1=CC=C(C(/C=C/C2=CC(C)=C(OC(C)(C)C(O)=O)C(C)=C2)=O)C=C1
InChIKey
AFLFKFHDSCQHOL-IZZDOVSWSA-N
NCBI gene ID
5467
UniProt ID
Q03181
Synonyms
NUC1, NUCII, FAAR, NR1C2
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/acsmedchemlett.9b00189
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037