Compound name
Lanifibranor
Protein family
NR
Target name
PPARD
Affinity on-target cellular (nM)
900
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001149a
SMILES
O=S(C1=CC(SC=N2)=C2C=C1)(N3C(CCCC(O)=O)=CC4=C3C=CC(Cl)=C4)=O
InChIKey
OQDQIFQRNZIEEJ-UHFFFAOYSA-N
NCBI gene ID
5467
UniProt ID
Q03181
Synonyms
NUC1, NUCII, FAAR, NR1C2
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/acs.jmedchem.7b01285
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(PPARA) = 5.01, inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1