Compound name
SR8278
Protein family
NR
Target name
NR1D1
Affinity on-target cellular (nM)
470
CG-Set
NR
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001153a
SMILES
O=C(OCC)C1N(C(C2=CC=C(SC)S2)=O)CC3=CC=CC=C3C1
InChIKey
UIEBLUZPSFAFOC-UHFFFAOYSA-N
NCBI gene ID
9572
UniProt ID
P20393
Synonyms
ear-1, hRev, Rev-ErbAalpha, THRA1, REVERBA, REVERBalpha
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/cb1002575
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR4A1) = 2.05, inactive at 10 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1