Compound name
SR 3335 (ML-176)
Protein family
NR
Target name
RORB
Affinity on-target cellular (nM)
1500
CG-Set
NR
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001157a
SMILES
OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(NS(C2=CC=CS2)(=O)=O)C=C1
InChIKey
LZWUNZRMANFRAO-UHFFFAOYSA-N
NCBI gene ID
6096
UniProt ID
Q92753
Synonyms
RZRB, NR1F2, ROR-BETA
Mode of action
Inverse Agonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 10 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037