Compound name
(±)-ML 209
Protein family
NR
Target name
RORB
Affinity on-target cellular (nM)
1300
CG-Set
NR
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001161a
SMILES
COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O
InChIKey
YEKVAIMYYCZDLI-MCPYQZEQSA-N
NCBI gene ID
6096
UniProt ID
Q92753
Synonyms
RZRB, NR1F2, ROR-BETA
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
rem. activity(RORA) = 0.85, rem. activity(NR2C1) = 0.42, inactive at 10 µM for UL48, RXRA, HNF4A, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
2