Compound name
SR 9238
Protein family
NR
Target name
NR1H3
Affinity on-target cellular (nM)
214
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001164a
SMILES
CS(C1=CC=CC(C2=CC=C(CN(CC3=CC=C(C(OCC)=O)O3)S(C4=C(C)C=C(C)C=C4C)(=O)=O)C=C2)=C1)(=O)=O
InChIKey
HDZWHJYZJWLTAG-UHFFFAOYSA-N
NCBI gene ID
10062
UniProt ID
Q13133
Synonyms
LXR-a, RLD-1, LXRa
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/cb300541g
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037