Compound name
Cilofexor
Protein family
NR
Target name
NR1H4
Affinity on-target cellular (nM)
40
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001168a
SMILES
OC(C1=CC=NC(N2CC(C3=C(Cl)C=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3)(O)C2)=C1)=O
InChIKey
KZSKGLFYQAYZCO-UHFFFAOYSA-N
NCBI gene ID
9971
UniProt ID
Q96RI1
Synonyms
FXR, RIP14, HRR1, HRR-1
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/acs.jmedchem.9b01701
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR1H2) = 5.01, inactive at 1 µM for NR1H3, UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1