Compound name
CintiRORCon
Protein family
NR
Target name
RORC
Affinity on-target cellular (nM)
21
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001172a
SMILES
O=S(N1C(C=C2C3=CC(F)=CC(OC(F)F)=C3)=C(C=C2)O[C@@H](CC(C)(C)C(O)=O)C1)(C4=CC(C(F)(F)F)=CC=C4)=O
InChIKey
GULSIMHVQYBADX-UHFFFAOYSA-N
NCBI gene ID
6097
UniProt ID
P51449
Synonyms
RZRG, RORG, NR1F3, TOR
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016201225
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037