Compound name
LY2562175
Protein family
NR
Target name
NR1H4
Affinity on-target cellular (nM)
200
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001173a
SMILES
CN1C=C(C(O)=O)C2=CC=C(N3CCC(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)CC3)C=C21
InChIKey
RPVDFHPBGBMWID-UHFFFAOYSA-N
NCBI gene ID
9971
UniProt ID
Q96RI1
Synonyms
FXR, RIP14, HRR1, HRR-1
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
doi.org/10.1021/acs.jmedchem.5b01161
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR1H2) = 5.89, inactive at 1 µM for NR1H3, UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1