Compound name
DY 268
Protein family
NR
Target name
NR1H4
Affinity on-target cellular (nM)
468
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001174a
SMILES
CC(C=C1)=CC=C1C2=NN(CC3=CC=CC(OC)=C3)C=C2C(NC4=CC=C(C)C(S(N5CCOCC5)(=O)=O)=C4)=O
InChIKey
KQSPAAPFKIEUGH-UHFFFAOYSA-N
NCBI gene ID
9971
UniProt ID
Q96RI1
Synonyms
FXR, RIP14, HRR1, HRR-1
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1016/j.bmc.2014.04.014
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
rem. activity(NR1H2) = 0.62, rem. activity(NR1H3) = 0.72, rem. activity(NR2E1) = 0.43, inactive for UL48, RXRA, HNF4A, NR2C1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
3