Compound name
WHI-P180
Protein family
Protein Kinase
Target name
TTBK1
Affinity biochemical (nM)
240
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001196a
SMILES
COC1=C(OC)C=C(C(NC2=CC=CC(O)=C2)=NC=N3)C3=C1
InChIKey
BNDYIYYKEIXHNK-UHFFFAOYSA-N
NCBI gene ID
84630
UniProt ID
Q5TCY1
Synonyms
KIAA1855
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
SPR
Affinity Biochemical Source Knowledge
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201300274
Affinity biochemical relation
=
Selectivity platform
Kinase panel (DSF assay, SGC Frankfurt)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 10 µM, closest target dTm(STK10) = 4.2K, all other targets dTm <4 K;
Selectivity Source Knowledge
https://www.pnas.org/doi/full/10.1073/pnas.0708800104#sec-3
Selectivity Number of Off-targets
1