Compound name
PF-05236216
Protein family
Protein Kinase
Target name
CSNK1D
Affinity biochemical (nM)
8
Affinity on-target cellular (nM)
58
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001199aCl
SMILES
CN1C=C(C2=CC=NC(CN3C)=C2C3=O)C(C4=CC=C(F)C=C4)=N1.Cl
InChIKey
CLDJMFXSCFWXDI-UHFFFAOYSA-N
NCBI gene ID
1453
UniProt ID
P48730
Synonyms
HCKID, CKID, CKIdelta
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Kinase-Glo Plus Assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acschemneuro.7b00155
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Translocation Assay (CSNK1D mediated PER3 nuclear translocation in COS-7 cells)
Affinity on-target cellular source knowledge
https://pubs.acs.org/doi/10.1021/acschemneuro.7b00155
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (literature)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 1 µM, closest targets as % of inhibition: MAP4K4 (65%), CSNK1A1 (51%), MINK1 (42%), MAPK14 (37%), in-vitro potencies of closest targets: IC50(MAP4K4) = 873 nM, IC50(CSNK1A1) = 630 nM, IC50(MINK1) = 1573 nM, IC50(MAPK14) = 861 nM (https://pubs.acs.org/doi/10.1021/acschemneuro.7b00155);
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/acschemneuro.7b00155