Compound name
MU1742
Protein family
Protein Kinase
Target name
CSNK1A1
Affinity biochemical (nM)
7.2
Affinity on-target cellular (nM)
3500
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001205a
SMILES
CN1CCC(F)(Cn2cnc(-c3ccc(F)cn3)c2-c2ccnc3[nH]ccc23)CC1
InChIKey
SWOIFXHMBKFCRM-UHFFFAOYSA-N
NCBI gene ID
1452
UniProt ID
P48729
Synonyms
CK1, CK1a, CK1alpha, CKIa, CKIalpha
Mode of action
Inhibitor
Negative control
MU2027
Affinity biochemical definition
IC50
Affinity biochemical assay type
Eurofins radiometric assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/mu1742
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET asssay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/mu1742
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (Reaction Biology)
Selectivity platform number of targets
415
Selectivity remarks
Screened at 1 µM, closest targets as % of inhibition: CSNK1A1 (6%), CSNK1D (-6%), CSNK1E (0%), TNIK (43%), ZAP-70 (71%);
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/mu1742