Compound name
GSK840
Protein family
Protein Kinase
Target name
RIPK3
Affinity biochemical (nM)
0.9
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001243b
SMILES
O=C(OC(C)(C)C)CC1=CC=C(N2C3=CC=C(C(NC)=O)C=C3N=C2)C=C1
InChIKey
UGTLDBJIOSYXRR-UHFFFAOYSA-N
NCBI gene ID
11035
UniProt ID
Q9Y572
Synonyms
RIP3
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescence Polarization Binding Assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25459880/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (enzymatic assay using 10 μM P32-Labeled ATP.)
Selectivity platform number of targets
301
Selectivity remarks
Screened at 1 µM, closest targets as % of control: LCK (13%), FLT3(16%), BRK (31%), full screening data available as supporting information
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25459880/
Selectivity Number of Off-targets
0