Compound name
SB-633825
Protein family
Protein Kinase
Target name
STK10
Affinity biochemical (nM)
66
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001302a
SMILES
COc1ccc2cc(-c3c(-c4ccncc4)nc(-c4ccc(S(C)(=O)=O)cc4C)n3C)ccc2c1
InChIKey
ZDSNJSQTPLXCSG-UHFFFAOYSA-N
NCBI gene ID
6793
UniProt ID
O94804
Synonyms
LOK, PRO2729
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Caliper assay (using ATP = Km)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26501955/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Nanosyn)
Selectivity platform number of targets
230
Selectivity remarks
Screened at 1 µM, Caliper assay (microfluidics capillary electrophoresis technology), using conc. ATP=Km, closest targets as % of inhibition: STK10 (95.26%), BRK (84.98%), TEK (78.74%), KDR (47.78%), ERBB4 (44.38%), also screened at 0.1 µM, closest targets as % of inhibition: TEK (75%), STK10 (43.93%), BRK (29.02%), ERBB4 (15.02%), full screening data are available at Chembl., https://pubmed.ncbi.nlm.nih.gov/26501955/
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26501955/
Selectivity Number of Off-targets
1