Compound name
GSK114
Protein family
Protein Kinase
Target name
TNNI3K
Affinity biochemical (nM)
25
Affinity on-target cellular (nM)
100
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001336a
SMILES
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OC)c(OC)cc23)c1
InChIKey
YUSROMRPOFFTMX-UHFFFAOYSA-N
NCBI gene ID
51086
UniProt ID
Q59H18
Synonyms
CARK
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescence polarization assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27246618/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
TR-FRET assay (TNNI3K autophosphorylation in HEKMSRII cells overexpressing human myc-TNNI3K)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/27246618/
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (Reaction Biology)
Selectivity platform number of targets
294
Selectivity remarks
Screened at 1 µM, closest targets as % of inhibition: TNK2 (85%), PDGFRB (84%), ZAK (86%), full screening data available as supporting information
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27246618/
Selectivity Number of Off-targets
0