Compound name
TPKI-24
Protein family
Protein Kinase
Target name
DAPK3
Affinity biochemical (nM)
70
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001350a
SMILES
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C
InChIKey
DJNZZLZKAXGMMC-UHFFFAOYSA-N
NCBI gene ID
1613
UniProt ID
O43293
Synonyms
ZIP, ZIPK
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Binding assay (Ambit), Binding assay (Ambit)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/22172702/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Ambit)
Selectivity platform number of targets
293
Selectivity remarks
Screened at 1 µM, in-vitro potency of closest targets (binding assay, Ambit): Kd(ALK) = 230 nM, Kd(CAMKK1) = 1100 nM, Kd(CAMKK2) = 87 nM, Kd(DAPK1) = 100 nM, Kd(DAPK3) = 70 nM, Kd(FER) = 53 nM, Kd(GAK) = 87 nM, Kd(MYLK) = 170 nM, Kd(PTK2) = 84 nM, Kd(PTK2B) = 130 nM, Kd(RPS6KA6) = 560 nM, Kd(TTK) = 51 nM, Kd(PLK1) = 0.09 nM, https://pubmed.ncbi.nlm.nih.gov/22172702/;
Selectivity Number of Off-targets
4