Compound name
hSMG-1 inhibitor 11j
Protein family
Protein Kinase
Target name
PIK3CA
Affinity biochemical (nM)
92
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001448b
SMILES
CCN(CC)S(=O)(=O)c1cc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)ccc1Cl
InChIKey
RZFJBSIAXYEPBX-UHFFFAOYSA-N
NCBI gene ID
5290
UniProt ID
P42336
Synonyms
PI3K
Mode of action
inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (Caliper Life Sciences)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23021994/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, clean profile, no target with dTm >2 K, in-house data;
Screened against 25 kinases in enzymatic assays, in-vitro potency of closest targets: IC50(GSK3A) = 260 nM, IC50(GSK3B) = 330 nM, others >10 µM, but targets not named in the literature, https://pubmed.ncbi.nlm.nih.gov/23021994/;
Screened against 25 kinases in enzymatic assays, in-vitro potency of closest targets: IC50(GSK3A) = 260 nM, IC50(GSK3B) = 330 nM, others >10 µM, but targets not named in the literature, https://pubmed.ncbi.nlm.nih.gov/23021994/;
Selectivity Number of Off-targets
0