Compound name
hSMG-1 inhibitor 11j
Protein family
Protein Kinase
Target name
PIK3CG
Affinity biochemical (nM)
60
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001448b
SMILES
CCN(CC)S(=O)(=O)c1cc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)ccc1Cl
InChIKey
RZFJBSIAXYEPBX-UHFFFAOYSA-N
NCBI gene ID
5294
UniProt ID
P48736
Mode of action
inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (Caliper Life Sciences)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23021994/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, clean profile, no target with dTm >2 K, in-house data;
Screened against 25 kinases in enzymatic assays, in-vitro potency of closest targets: IC50(GSK3A) = 260 nM, IC50(GSK3B) = 330 nM, others >10 µM, but targets not named in the literature, https://pubmed.ncbi.nlm.nih.gov/23021994/;
Screened against 25 kinases in enzymatic assays, in-vitro potency of closest targets: IC50(GSK3A) = 260 nM, IC50(GSK3B) = 330 nM, others >10 µM, but targets not named in the literature, https://pubmed.ncbi.nlm.nih.gov/23021994/;
Selectivity Number of Off-targets
0