Compound name
SGC-STK17B-1
Protein family
Protein Kinase
Target name
STK17B
Affinity biochemical (nM)
43
Affinity on-target cellular (nM)
190
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001453a
SMILES
O=C(O)CSc1ncnc2cc(-c3cc4ccccc4s3)sc12
InChIKey
BNYXRPMABDQJJR-UHFFFAOYSA-N
NCBI gene ID
9262
UniProt ID
O94768
Synonyms
DRAK2
Mode of action
Inhibitor
Negative control
SGC-STK17B-1N (UNC-AP-301)
Affinity biochemical definition
IC50
Affinity biochemical assay type
Binding assay performed at Luceome Biotechnologies
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/SGC-STK17B-1
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/SGC-STK17B-1
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, closest targets as % of control: MET (0%), NEK6 (0%), PIM2 (0%), WEE1 (0%), STK17B (0.9%), CAMKK2 (7.8%), AURKA (14%), CAMKK1 (14%), STK38L (29%), CDKL1 (40%), HIPK1 (41%), HIPK4 (41%), HIPK2 (53%), STK17A (73%), STK16 (77%), https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(MET) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(NEK6) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(WEE1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK17B) = 34 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CAMKK2) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(AURKB) = 8947 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CAMKK1) = 5183 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK38L) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CDKL1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK4) = 4352 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK2) = 8612 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK17A) = 4666 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK16) = 648 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(AURKB) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(STK38L) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK4) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK2) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(STK16) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(MET) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(NEK6) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(WEE1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK17B) = 34 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CAMKK2) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(AURKB) = 8947 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CAMKK1) = 5183 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK38L) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(CDKL1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK4) = 4352 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(HIPK2) = 8612 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK17A) = 4666 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-vitro potency (enzymatic assay): Kd(STK16) = 648 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(AURKB) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(STK38L) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK1) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK4) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(HIPK2) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
In-cellular potency (NanoBRET assay, HEK293T cells): IC50(STK16) >10000 nM, https://www.thesgc.org/chemical-probes/SGC-STK17B-1;
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/SGC-STK17B-1
Selectivity Number of Off-targets
0