Compound name
DCLK1-IN-1
Protein family
Protein Kinase
Target name
DCLK2
Affinity biochemical (nM)
31
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001463a
SMILES
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2CC(F)(F)F
InChIKey
OQFCHSFVWSLDAO-UHFFFAOYSA-N
NCBI gene ID
166614
UniProt ID
Q8N568
Synonyms
MGC45428, DCDC3, DCDC3B, DCK2
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Binding assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/32251410/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
489
Selectivity remarks
Screened at 1 µM, closest targets as % of control: DCAMKL2(1.9%), DCAMKL1(5.9%), HIPK4 (44%), ABL1 (44%), full screening data available as supporting information; Screened at 2.5 µM, in activity-based proteomic profiling against 250 kinases using KiNativ assay profiling in PATU-8988T cell lysates, closest targets as % of inhibition: DCAMKL1 (52.3%), TBK1 (43.6%), DCAMKL1 (40.1%), MAPK15(36%), full screening data available as supporting informatio, https://pubmed.ncbi.nlm.nih.gov/32251410/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/32251410/
Selectivity Number of Off-targets
0