Compound name
M4K2234NC
Protein family
Protein Kinase
Target name
ACVR1
Affinity on-target cellular (nM)
5686
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001465a
SMILES
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(=O)N1CCCC1
InChIKey
WFJOMSKCDAOJBT-UHFFFAOYSA-N
NCBI gene ID
90
UniProt ID
Q04771
Synonyms
SKR1, ALK2, ACVR1A
Mode of action
negative control
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/m4k2234
Affinity on-target cellular relation
=
Selectivity platform
ALK family panel (NanoBRET assay in HEK293T cells , in-house data SGC-Frankfurt)
Selectivity platform number of targets
6
Selectivity remarks
In-cellulo follow-up (NanoBRET assays in HEK293T cells): IC50(ALK3) >10 µM, IC50(ALK4) >10 µM, IC50(ALK5) >10 µM, IC560(ALK6) = >10 µM; https://www.thesgc.org/chemical-probes/m4k2234
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/m4k2234