Compound name
Calcitriol
Protein family
NR
Target name
VDR
Affinity on-target cellular (nM)
100
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001478a
SMILES
O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@]3([C@H](C)CCCC(C)(O)C)[H])([H])[C@]3(C)CCC\2
InChIKey
GMRQFYUYWCNGIN-NKMMMXOESA-N
NCBI gene ID
7421
UniProt ID
P11473
Synonyms
NR1I1, PPP1R163
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
https://doi.org/10.1021/acs.jmedchem.6b00182
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for NR1I2, NR1I3, UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037