Compound name
MR7
Protein family
Protein Kinase
Target name
SIK2
Affinity on-target cellular (nM)
14000
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001479a
SMILES
CN(C)c1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1
InChIKey
RRFFBKGCCWPMLK-OQIWPSSASA-N
NCBI gene ID
23235
UniProt ID
Q9H0K1
Synonyms
KIAA0781, QIK, DKFZp434K1115, LOH11CR1I
Mode of action
Negative control for MRIA9
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/mria9
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (DSF assay, SGC-Frankfurt)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, clean selectivity profile, dTm(MST3) = 0.2 K, dTm(MST4) = 0.8 K, dTM(PAK1) = 0.9 K
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/mria9