Compound name
RGX-104
Protein family
NR
Target name
NR1H2
Affinity on-target cellular (nM)
2900
CG-Set
NR
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001482aCl
SMILES
CC(N(CC(C1=CC=CC=C1)C2=CC=CC=C2)CC3=C(Cl)C(C(F)(F)F)=CC=C3)CCOC4=CC=CC(CC(O)=O)=C4.Cl
InChIKey
LCMIYQOJZLRHTO-GJFSDDNBSA-N
NCBI gene ID
7376
UniProt ID
P55055
Synonyms
NER, NER-I, RIP15, LXR-b, LXRb
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 10 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037