Compound name
A-426
Target name
GLS
Affinity biochemical (nM)
30000
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001486a
SMILES
O=C(Cc1ccccc1)Nc1nnc(N2CC[C@@H]3[C@H]2CN3c2cccnn2)s1
InChIKey
VCDTXROFDBHEIP-HUUCEWRRSA-N
NCBI gene ID
2744
UniProt ID
O94925
Synonyms
GLS, GLS1, KIAA0838
Mode of action
Negative control for A-446
Affinity biochemical definition
IC50
Affinity biochemical assay type
GLS Enzyme activity assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/A-446
Affinity biochemical relation
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Selectivity remarks
Selectivity within target family (GLS2 enzyme activity assay): IC50 >30 µM (>1000 fold)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/A-446