Compound name
CKJB71
Protein family
Protein Kinase
Target name
STK17A
Affinity on-target cellular (nM)
45000
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001489b
SMILES
CN1CCN(C(=O)c2ccc3cc2OCCOCCNc2ccn4ncc-3c4n2)CC1
InChIKey
DDXOMWWURGFLKK-UHFFFAOYSA-N
NCBI gene ID
9263
UniProt ID
Q9UEE5
Synonyms
DRAK1
Mode of action
Negative control for CK156
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Nano BRET assay (intact HEK293T cells)
Affinity on-target cellular source knowledge
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c00173
Affinity on-target cellular relation
>
Selectivity platform
Kinase panel (DSF assay, in-house data SGC Frankfurt)
Selectivity platform number of targets
90
Selectivity remarks
Screened at 20 µM, dTm values of closest targets: dTm(BMP2K) = 6.8 K, dTm(AAK1) = 4.2 K, dTm(STK6) = 4.2 K, dTm(PLK4) = 4.0 K, dTm(STK3) = 3.4 K, dTm(MAP3K5) = 3.32 K, dTm(FLT1) = 2.9 K, dTm(CLK1) = 2.9 K, dTm(STK10) = 2.3 K, dTm(PIM3) = 2.1 K, dTm(STK17A) = 1.5K;
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/ck156