Compound name
GDC-046
Protein family
Protein Kinase
Target name
TYK2
Affinity biochemical (nM)
4.8
Affinity on-target cellular (nM)
380
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001544a
SMILES
O=C(Nc1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cccc1Cl
InChIKey
IAFNAEGXTKTGHN-UHFFFAOYSA-N
Mode of action
inhibitor
Affinity biochemical definition
Ki
Affinity biochemical assay type
Biochemical assay
Affinity Biochemical Source Knowledge
https://www.sciencedirect.com/science/article/pii/S0223523413002304?via%3Dihub
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Cell-based assay (Meso Scale Discovery technology, IL-12 stimulated phosphorylation of STAT4 in NK92 cells)
Affinity on-target cellular source knowledge
https://www.sciencedirect.com/science/article/pii/S0223523413002304?via%3Dihub
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
185
Selectivity remarks
Screened at 0.5 µM, in-vitro potency of closest target: Ki(CDK9) = 110 nM, others >50-fold selective for TYK2
Selectivity Source Knowledge
https://www.sciencedirect.com/science/article/pii/S0223523413002304?via%3Dihub
Selectivity Number of Off-targets
1