Compound name
BAY-283
Protein family
Protein Kinase
Target name
BUB1
Affinity biochemical (nM)
1700
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001549a
SMILES
COc1ccccc1Nc1nc(-c2nn(Cc3c(F)cc(OCCCO)cc3F)c3ccccc23)ncc1OC
InChIKey
PYAFWWXPXHSNDM-UHFFFAOYSA-N
NCBI gene ID
699
UniProt ID
O43683
Synonyms
hBUB1, BUB1A
Mode of action
Negative control for BAY 1816032
Affinity biochemical definition
IC50
Affinity biochemical assay type
TR-FRET kinase assay (at 10 µM ATP)
Affinity Biochemical Source Knowledge
https://aacrjournals.org/clincancerres/article/25/4/1404/10115/Inhibition-of-BUB1-Kinase-by-BAY-1816032
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Bayer)
Selectivity platform number of targets
25
Selectivity remarks
IC50 >20 µM for all targets tested
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY%201816032