Compound name
BAY-091
Protein family
Protein Kinase
Target name
PIP4K2A
Affinity biochemical (nM)
21
Affinity on-target cellular (nM)
1100
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001564a
SMILES
CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O
InChIKey
DVIVLYHDLNAXAT-NRFANRHFSA-N
NCBI gene ID
5305
UniProt ID
P48426
Synonyms
PIP5KIIA, PIP5KIIalpha
Mode of action
Inhibitor
Negative control
BAY-0361
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (Eurofins)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-091
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
CETSA (intact K-562 cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-091
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (Eurofins)
Selectivity platform number of targets
373
Selectivity remarks
Screened at 1 µM, clean selectivity profile with no kinase inhibited >60%; Screened at 10 µM against 77 targets outside the target family (Eurofins safety panel), closest targets as % of inhibition: TBXAS1 (98%), HTR2B (98%), MAOB (81%), PDE3 (74%), PDE5A (62%);
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-091