Compound name
MSC-0516
Protein family
Ion Channel
Target name
SLC16A3
Affinity on-target cellular (nM)
506
CG-Set
Ion Channel
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001567a
SMILES
COc1cc(C(=O)O)ncc1C#Cc1ccccc1NS(=O)(=O)c1cccc2c(N(C)C)ccnc12
InChIKey
MMSNEMMBFRAGPO-UHFFFAOYSA-N
NCBI gene ID
9123
UniProt ID
O15427
Synonyms
MCT 3 MCT 4 MCT-3 MCT-4 MCT3 MCT4
Mode of action
Negative control for MSC-4381
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Lactate efflux inhibition assay (MDA-MB-231 cells expressing SLC16A3)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!detailedpotencydataview/MSC-4381
Affinity on-target cellular relation
0
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(OPRD1) = 597.96 nM, Ki(GABA/PBR) = 733.68 nM, Ki(HTR6) = 1523.62 nM, Ki(SLC6A3) = 9585.29 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/MSC-4381
Selectivity Number of Off-targets
2