Compound name
JNJ-53721590
Protein family
Nuclear Receptor
Target name
RORC
Affinity biochemical (nM)
515.7
Affinity on-target cellular (nM)
670
CG-Set
NR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001569a
SMILES
COc1nc2ccc([C@@](O)(c3ccc(Cl)cc3)c3cncn3C)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1
InChIKey
UWOBQISTECYGOP-HKBQPEDESA-N
NCBI gene ID
6097
UniProt ID
P51449
Synonyms
RZRG, RORG, NR1F3, TOR
Mode of action
Negative control for JNJ-54119936
Negative control
Affinity biochemical definition
qKd
Affinity biochemical assay type
ThermoFlour binding assay (RORC)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!detailedpotencydataview/JNJ-54119936
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
One-hybrid reporter assay (HEK293T cells co-transfected with pFR-Luc reporter and pRL-CMV reporter, pCMV-BD containing the GAL4 DNA-binding domain fused with full-length human RORγt using 6 µM compound)
Affinity on-target cellular source knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155022/
Affinity on-target cellular relation
0