Compound name
JNJ-40573663
Target name
PDE10A
Affinity biochemical (nM)
10000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001571a
SMILES
c1ccc(C2CCN(c3cnc4c(N5CCOCC5)nccn34)CC2)cc1
InChIKey
OKTXMSSTNJXZII-UHFFFAOYSA-N
NCBI gene ID
10846
UniProt ID
Q9Y233
Synonyms
PDE10A
Mode of action
Negative control for JNJ-42396302
Affinity biochemical definition
IC50
Affinity biochemical assay type
In-vitro assay (recombinant human PDE10A)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/JNJ-42396302
Affinity biochemical relation
>
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(GABAA) = 1.822 µM, Ki(SLC6A3) = 4.132 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/JNJ-42396302
Selectivity Number of Off-targets
0