Compound name
TP-040n
Target name
OGA
Affinity biochemical (nM)
10000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001573a
SMILES
CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1
InChIKey
BNXNWRSVYQHTOH-UHFFFAOYSA-N
NCBI gene ID
10724
UniProt ID
O60502
Synonyms
OGA, HEXC, KIAA0679, MEA5, MGEA5
Mode of action
Negative control for TP-040
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescent enzymatic assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/TP-040
Affinity biochemical relation
>
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(HRH3) = 92.76 nM, Ki(SIGMAR1) = 125.1 nM, Ki(HRH2) = 148.82, Ki(HTR2C) = 266.79 nM, Ki(HTR2B) = 290.75 nM, Ki(HTR7) = 334.53 nM, Ki(ADRA2C) = 414.29 nM, Ki(ADRA2B) = 475.35 nM, Ki(HTR6) = 606.4 nM, Ki(HTR2A) = 757.58 nM, Ki(HRH4) = 711.87 nM, Ki(SLC6A3) = 864.98 nM, Ki(TMEM97) = 1463.21 nM, Ki(HTR1D) = 2037.31, Ki(SLC6A2) = 3112.25 nM, Ki(HTR5A) = 6131.61 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!gpcrscandataview/TP-040
Selectivity Number of Off-targets
1