Compound name
JYQ88
Target name
UCHL1@Protease
Affinity biochemical (nM)
12900
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001575a
SMILES
N#CN1CC[C@@H](C(=O)Nc2nc3c(s2)CN(C(=O)CN=[N+]=[N-])CC3)C1
InChIKey
KIWKRCCIHSGWQS-SECBINFHSA-N
NCBI gene ID
7345
UniProt ID
P09936
Synonyms
HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, SPG79, Uch-L1
Mode of action
Negative control for 8RK64
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical activity-assay using a fluorogenic Ub-Rho-morpholine (inhibition of UCHL1 using 2 mM cysteine)
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/jacs.0c07726
Affinity biochemical relation
0
Selectivity platform
GPCR panel (PDSD screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potency of closest target: Ki(SLC6A3) >10 µM, Ki(ADRA2A) >10 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!gpcrscandataview/8RK64
Selectivity Number of Off-targets
0