Compound name
BI-5026
Protein family
Protein Kinase
Target name
IKBKB
Affinity biochemical (nM)
10000
Affinity on-target cellular (nM)
20000
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001576a
SMILES
CN(C)C(=O)c1sc2nc(N3CCC(S(C)(=O)=O)CC3)cc(C(F)(F)F)c2c1N
InChIKey
HHYGVXHXNNIDJF-UHFFFAOYSA-N
NCBI gene ID
3551
UniProt ID
O14920
Synonyms
IKK2, NFKBIKB, IKK-beta, IKKB
Mode of action
Negative control for BI 605906
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20605906
Affinity biochemical relation
>
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20605906
Affinity on-target cellular relation
>
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(SLC6A3) = 4270.11 nM, Ki(TMEM97) = 7307.71 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20605906