Compound name
BI-207127
Target name
HCV:NS5B
Affinity biochemical (nM)
19
Affinity on-target cellular (nM)
23
CG-Set
Protease set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001577a
SMILES
Cn1c(C2(NC(=O)c3ccc4c(C5CCCC5)c(-c5ncc(Br)cn5)n(C)c4c3)CCC2)nc2ccc(/C=C/C(=O)O)cc21
InChIKey
BMAIGAHXAJEULY-UKTHLTGXSA-N
NCBI gene ID
951475
UniProt ID
P27958
Synonyms
p23
Mode of action
Inhibitor
Negative control
BI-7656
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (using HCV NS5B polymerase D21)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20207127
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cell-based replication assay (Genotyp 1a, Huh7 cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20207127
Affinity on-target cellular relation
0
Selectivity platform
SafetyScreen44TM (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM, closest targets as % of contr.: CCKA/H (12%), DELTA2/H (47%)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI%20207127
Selectivity Number of Off-targets
0