Compound name
BI-2540
Target name
HIV:NNRT
Affinity biochemical (nM)
12
Affinity on-target cellular (nM)
0.76
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001578a
SMILES
Cc1c(NC(=O)COc2ccc(Cl)cc2C(=O)c2cc(F)cc(C(F)(F)F)c2)ccc(C(=O)O)c1F
InChIKey
WPEKGNGDNFRRMH-UHFFFAOYSA-N
NCBI gene ID
155348
UniProt ID
P04585
Synonyms
Pr160Gag-Pol
Mode of action
Inhibitor
Negative control
BI-2439
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (HIV1 reverse transcriptase picogreen fluorescence assay)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-2540
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
ELISA (HIV viral replication assay in C8166 cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-2540
Affinity on-target cellular relation
0
Selectivity platform
SafetyScreen44TM (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM, clean selectivity profile with no target <80% of contrl.
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-2540
Selectivity Number of Off-targets
0