Compound name
PIM447
Protein family
Protein Kinase
Target name
PIM2
Affinity biochemical (nM)
0.018
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001581a
SMILES
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1
InChIKey
VRQXRVAKPDCRCI-ZNMIVQPWSA-N
NCBI gene ID
11040
UniProt ID
Q9P1W9
Mode of action
inhibitor
Affinity biochemical definition
Ki
Affinity biochemical assay type
AlphaScreen assay (500 µM ATP)
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01275
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
442
Selectivity remarks
Screened at 1 µM, closest targets as % of control: MAPK15 (2.5%), others >20%;
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01275