Compound name
TMX-4116
Protein family
Protein Kinase
Target name
CSNK1A1
Affinity on-target cellular (nM)
200
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001621a
SMILES
COc1c(-c2cn(C3CCC(=O)NC3=O)nn2)csc1C(=O)N1CCCC1
InChIKey
OOIINFBRWZQRRM-UHFFFAOYSA-N
NCBI gene ID
1452
UniProt ID
P48729
Synonyms
CK1, CK1a, CK1alpha, CKIa, CKIalpha
Mode of action
Inhibitor, glue degrader
Affinity on-target cellular definition
DC50
Affinity on-target cellular assay type
Immunoblot assay (using MOLT4 cells, 4h incubation)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/34965125/
Affinity on-target cellular relation
<
Selectivity platform
Proteomics (using MOLT4 cells)
Selectivity platform number of targets
>300
Selectivity remarks
Screened at 200 nM, clean proteome-wide degradation selectivity, only target found CSNK1A1;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/34965125/
Selectivity Number of Off-targets
0