Compound name
YKL 5-124
Protein family
Protein Kinase
Target name
CDK7
Affinity biochemical (nM)
9.7
Affinity on-target cellular (nM)
62.5
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001635a
SMILES
C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)cc1
InChIKey
KPABJHHKKJIDGX-JOCHJYFZSA-N
NCBI gene ID
1022
UniProt ID
P50613
Synonyms
CAK1, CDKN7, MO15, STK1, CAK
Mode of action
Covalent inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Adapta Eu kinase assay (for CDK7/CycH/MNAT1 using ATP = Km)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/30905681/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Radioactive in vitro kinase assays (from cellular wild-type CDK7 immunoprecipitated in HeLa cells)
Affinity on-target cellular source knowledge
https://www.sciencedirect.com/science/article/pii/S2451945619300674?via%3Dihub
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (KiNativ target engagement assay in Jurkat cells)
Selectivity platform number of targets
233
Selectivity remarks
Screened at 1 µM, closest targets as % of engagement: CDK7 (95.5%), MARK4(93.3%), AMPK1 (54.4%), AMPK2(53.5%), MST3(41.8%), CAMK2G (35.8%), CAMK2D(34.1%), TBK1(32.4%), SNRK(30.4%)
Selectivity Source Knowledge
https://www.sciencedirect.com/science/article/pii/S2451945619300674?via%3Dihub